Every piece has a square decided in advance, which is what makes it a system: the same six moves against almost anything, and no theory to forget. The pay-off is the break e3–e4, which opens the position at the moment Black's pieces are least ready for it.
The famous attack is the one that follows: bishop on d3, knight to e5, queen to e2, rook to e1, all pointing at h7. It works because Black's light-squared bishop is so often stuck behind a pawn on e6 — which is also the clue to when the Colle is the wrong choice.